| abstract |
FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to compound of the formula: or its pharmaceutically acceptable salt wherein R 1 represents tetrazolyl; each of R 4 , R 5 , R 2 is taken independently among hydrogen atom, alkyl, alkoxy-group, hydroxy-group, halogen atom and so on; or aryl, possibly substituted CON(R 9 ) 2 , NHCOR 9 , SO 2 N(R 9 ) 2 , CO 2 R 9 ; wherein R 9 represents hydrogen atom, alkyl, cycloalkyl and so on; R 3 represents halogen atom or phenyl being phenyl can be substituted once or more times with substituents taken among alkyl, hydroxy-group, alkoxy-group, halogen atom and so on; Y represents - NHCONH-; each of R 11 , R 12 , R 13 , R 14 , R 15 is taken independently among hydrogen atom, alkyl, alkoxy-group, hydroxy-group, halogen atom, trifluoromethyl, cyano-group, nitro-group, amino-group, alkylamino-group, -COOR 7 ,-CO-R 7 and so on wherein R 7 represents hydrogen atom, alkyl, cycloalkyl or cycloalkylalkyl and so on. Invention proposes pharmaceutical compositions as antagonist of chlorine ions channels containing compound with at least one pharmaceutically acceptable carrier or excipient. Composition contains compound by cl. 1 as an active compound in combination with one or more compound known for treatment of osseous metabolic disorders, or pharmaceutically acceptable salt of these compounds. Invention proposes method for treatment of disorder or disease of live animal body. Invention provides preparing substituted phenyl derivatives that are strongly acting antagonists of chlorine ions channels. EFFECT: improved preparing method, valuable medicinal properties of compounds. 14 cl, 3 tbl |