| abstract |
FIELD: organic chemistry, peptides, pharmacy. SUBSTANCE: invention relates to the novel compound peptide of the general formula: Thr-Gly-Glu-Asn- His-Arg eliciting biological activity in inducing differentiation and inhibition of proliferation of cancer tumors and activity of protective and normalizing effect with respect to vitality processes of mammalian cells. Peptide is prepared by method of solid-phase synthesis by successive elongation of peptide chain and showing the following properties: molecular mass is 714 ± 1 Da; isoelectric point at 7.18; pH stability in the range of pH from 2.0 to 9.0; thermal stability in the range of temperature from 0 to +50 C; homogenicity is 99.8%. Peptide is soluble in water, physiological solutions and buffer solutions with pH = 2.0-9.0, it has no immunogenicity and toxicity. Invention relates also to pharmaceutical composition containing indicated peptide taken in the effective dose as an active component. EFFECT: valuable medicinal properties of peptide and composition. 2 cl, 9 dwg,, 4 ex |