| abstract |
FIELD: organic chemistry, biochemistry, amino acids, pharmacy. SUBSTANCE: invention relates to derivatives of amino acids of the formula (I): or its nontoxic salt or its hydrate and to a pharmaceutical composition showing an inhibitory effect on calcium channel of iv-type, to an inhibitor of calcium channel of iv-type, to a pharmaceutical composition used for prophylaxis and/or treatment of patients with cerebral infarction and to a pharmaceutical composition used for the pain treatment. Values of radicals R 1 -R 4 are given in the description. EFFECT: valuable medicinal properties of compounds. 18 cl, 41 tbl, 3 sch, 143 ex |