| abstract |
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to pharmaceutical composition comprising testosterone undecanoate as a medicinal substance. Testosterone undecanoate is dissolved in liquid carrier that comprises long-chain saturated acid glyceride with from 14 to 22 carbon atoms, preferably long-chain triglyceride, and lipophilic surface-active substance with HLB value less 10, preferably, lauroglycol. Indicated liquid carrier does not comprise free fatty acids. The novel composition for oral administration provides the enhanced solubility of gonadal hormone, testosterone undecanoate, and shows improved stability at storage. Composition containing testosterone undecanoate can be used in capsule composites with soft gel and solid envelope successively. EFFECT: improved and valuable pharmaceutical properties of compositions. 18 cl, 15 ex |