http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2205831-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8484d9a5c4d2a277f2587d3ab9bb0dc4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
| filingDate | 1998-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2221b8e85eee192b0920d3ea4851ada5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56c51b682d5ffbcdff3ef0de834e1698 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48957ee2d749bd493897bccea57dee8f |
| publicationDate | 2003-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2205831-C2 |
| titleOfInvention | Quinazolinones inhibiting farnesyltransferase activity |
| abstract | FIELD: organic chemistry, biochemistry. SUBSTANCE: invention proposes derivatives of quinazolinone of the general formula (I) and their pharmaceutically acceptable acid-additive salts and stereochemical isomeric forms where dotted line is optionally linkage; X is oxygen atom; R 1 and R 2 each means independently hydrogen or halogen atom; R 3 and R 4 each means independently hydrogen or halogen atom; R 5 means hydrogen, halogen atom or radical of the formula -O-R 10 (a-1) or N-R 11 R 12 (a-3) where R 10 , R 11 , R 12 are hydrogen atom; R 6 means radical of the formula (b-1) or (b-2) where R 16 is hydrogen atom or phenyl; R 17 is hydrogen atom or C 1-6 -alkyl; R 7 is hydrogen atom or C 1-6 -alkyl under condition that dotted line is not a linkage; R 8 is hydrogen atom, C 1-6 -alkyl or Het 1 CH 2 ; R 9 is hydrogen atom; is pyridinyl. Compounds of the general formula (I) show inhibitory effect on farnesyltransferase activity and can be used for preparing medicinal agents inhibiting proliferative diseases. Invention relates also to pharmaceutical composition based on compounds of the general formula (I) eliciting inhibitory effect on farnesyltransferase activity, to method for preparing this composition, to intermediate derivatives of quinazolinone of the general formula (IX) and their acid-additive salts or stereochemical isomeric forms where n = 2 or 3 and R 1 , R 2 , R 3 , R 4 , R 9 , mean values indicated above, to method for preparing some compounds of the general formula (I) where R 6 is radical of the formula (b-2) and to method for preparing intermediate derivatives of quinazolinone of the general formula (IX) and their acid-additive salts or stereochemical isomeric forms. EFFECT: improved preparing method of compounds and composition, valuable medicinal and biochemical properties. 10 cl, 4 tbl, 15 ex |
| priorityDate | 1997-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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