abstract |
FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to novel 1,8-annelated derivatives of 2-quinolinone of the formula (I) where A, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 are given in the invention claim. Invention describes also method of synthesis of proposed compounds, pharmaceutical composition exhibiting inhibitory effect on farnesyl- transferase activity and method for its preparing. Invention discloses intermediate compounds useful for synthesis of proposed compounds and method of their synthesis also. Invention can be used in medicine as therapeutic agent. EFFECT: valuable medicinal properties. 11 cl, 7 tbl |