| abstract |
FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to novel spiroketals of the formula (I): where A 2 is phenyl, substituted phenyl where substituents are represented by: alkyl, alkoxyalkyl, phenoxy-group, halogen atom, pyridyloxy-group, alkoxy- alkoxy-group, halogenphenoxy-group; R 1 is hydrogen atom; R 2 is hydrogen atom, C 1 -C 4 -alkyl; W represents oxygen atom or one or some C 1 -C 4 -alkyl fragments; Y means independently one or some members of group consisting of H 2 , -SR 3 , alkoxy-group; R 3 is hydrogen atom; Z is carbocyclic or heterocyclic spiro-fragment with 3-7 members of ring system where heterocyclic fragment involves 2 oxygen or sulfur atoms, or one nitrogen atom being spiro-cycle can be unsubstituted or substituted with hydroxy-group, C 1 -C 4 -alkyl, benzyloxy-group; n = 1-3; optical isomers, diastereomers or enantiomers or their pharmaceutically acceptable salts. Compounds of the formula (I) inhibit activity of metalloprotease that ensures to use their in pharmaceutical composition for treatment or prophylaxis of disease associated with enhanced activity of metalloprotease. EFFECT: valuable medicinal properties of compounds. 10 cl, 5 tbl |