abstract |
FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to substituted 3-cyanoquinolines of the formula (1) where R 1 , R 2 , R 3 , R 4 , X and Y are given in the invention claim. Invention describes also methods of synthesis of these compounds, methods of treatment and inhibition using these compounds and pharmaceutical composition based on thereof. Invention can be used in medicine for treatment of diseases that are result of disturbance of regulation of some receptor protein tyrosine kinases. EFFECT: improved method of synthesis and treatment, valuable medicinal properties of compounds. 47 cl, 14 tbl _ |