http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2201932-C2

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f1df552c231d3f95a92c3f2d3491efb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_379835b2e0130f71eb926b8fa04dcf53
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04
classificationIPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-00
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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04
filingDate 1998-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2003-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15bc8c0c5e7640ec227f82df66f10919
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e572d0658e09822112a77c7011265ea3
publicationDate 2003-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2201932-C2
titleOfInvention Epotilons modified by by-side chain
abstract FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of preparing epotilons modified at 16,17-position. Method involves hydrogenation of non-protected epotilons A and B or that protected at position 3,7 (a) by double bond at position 16,17 or (b) method involves epoxidation reaction by double bond at position 16,17 and, if necessary, the prepared epoxide is reduced to alcohol at position 16. Invention relates also to method of preparing epotilon-N-oxides where non-protected or protected at position 3,7 epotilons A and B are converted to N-oxide. The prepared N-oxide if necessary is subjected for Catar's reaction. Invention relates to method of preparing epotilons modified at position C-19 by metallization reaction of protected or non-protected epotilons A and B at position C-19 and to modified epotilons of the general formula (I) given in the invention description. EFFECT: improved method of synthesis. 17 cl, 1 tbl, 4 ex
priorityDate 1997-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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