| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95a5fcf15b4376d54529206d03b7e57d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-081
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D339-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D339-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate |
1997-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e925b667904dc18eb1a9efd1bb825613 |
| publicationDate |
2003-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2201925-C2 |
| titleOfInvention |
Inhibitors of prenyltransferases |
| abstract |
FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) or the formula (II) where R 1 means N(R 10 )(R 11 ); R 2 means lower thioalkyl; each of R 3 and R 5 means independently CH 2 or C(O); R 4 means unsubstituted or substituted lower thioalkyl where CH 2 NHC(O)R 13 is a substituent and it is linked to the indicated thio-group; R 6 means a residue of heteroaromatic α-amino acid; R 7 means a residue of natural or synthetic α-amino acids; R 8 means OH or lower alkoxy-group or in common with R 7 it forms homoserine lactone; R 9 means H; each of R 10 and R 11 represents independently H; R 12 means unsubstituted or substituted fragment taken among aryl, aryl-lower alkyl where one or some lower alkyls or halogen atom are substituents; R 13 means lower alkyl; R 18 means H under condition that if R 4 means unsubstituted lower thioalkyl then free thio-groups from R 2 and R 4 can form disulfide bond; or its pharmaceutically acceptable salts. Compounds elicit ability to inhibit activity of prenyltransferases. Invention describes also pharmaceutical compositions comprising indicated compounds and method of inhibition of activity of prenyltransferase. EFFECT: valuable biochemical properties of compounds. 22 cl, 3 ex |
| priorityDate |
1996-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |