| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of benzofuryl-pyrone. Invention describes derivatives of benzofurylpyrone of the general formula (I): where radicals R 1 , R 2 , R 3 , R 4 are given in claim 1 of the invention claim. Invention describes also pharmaceutical composition based on compounds of the formula (I), enhancer of lipid metabolism, inhibitor of biosynthesis of triglycerides, agent reducing blood triglycerides content, agent enhancing content of HDL (high-density lipoproteins), agent used for prophylaxis of atherosclerosis and agent used for treatment of atherosclerosis. Invention provides synthesis of novel compounds eliciting useful biological properties. EFFECT: valuable medicinal and biochemical properties of compounds. 32 cl, 1 tbl, 315 ex |