| abstract |
FIELD: organic chemistry, amino acids. SUBSTANCE: invention relates to novel compounds of the formula (I) where R 1 means hydrogen atom or fragment of ester; E means hydrogen atom or hydroxy-group; X 1 -X 4 mean group C(R a ),C(R b ) or C(R c ) and fourth means C(R d ) or N where R a -R d mean hydrogen atom, alkenyl, alkynyl, alkenyloxy, alkoxy, alkylamino, alkoxyalkoxy, alkoxyalkyl-aminoalkyl, alkoxycarbonylalkyl, alkoxycarbonylarylalkoxy, alkoxy-carbonylalkylcarboxamido, alkyl, alkoxycarbonylcarboxamido, alkyl-sulfanyl, alkylsulfinyl, alkylsulfonyl, alkylureido, alkylthioureido, alkylsulfonylaminoalkoxy, alkylsulfonylamino, aminoalkoxy, arylalkenyl, arylalkoxy, arylalkyl, arylalkylcarboxamido, arylcarbonyl-alkoxy, Arylcarboxamido, aryloxy, aryloxyalkoxy, arylsulfonylamino, arylsulfonylaminoalkoxy, carboxy, carboxyalkyl, substituted alkyl, substituted amino, halogen atom, substituted halogen atom, cycloalkyl, substituted cycloalkyl, hydroxy-group, substituted hydroxy-group, heterocycle, substituted heterocycle; or two adjacent groups from R a -R d form in common fragment of condensed di- or mono-oxane ring or aryl ring. Indicated compounds exhibit amidolytic activity with respect to complex factor VIIa/tissue factor and owing to this property they can be used as active component in pharmaceutical composition and for treatment of different diseases caused by this activity. EFFECT: valuable biochemical activity and properties. 24 cl, 362 ex |