| abstract |
FIELD: medicine, immunology, oncology. SUBSTANCE: monoclonal antibody IKO25 exhibiting specificity to antigen MIS1 relates to IgG1 and has association constant 3 x 10 -5 M determined in model of human lung cancer cultured cells OAT75. Based on monoclonal antibody IKO25 antitumor agent is developed that comprises 0.5% of IKO25, 2.0% of polysorbate-80 and saline phosphate buffer, the balance. Invention allows to carry out the selective effect on tumor cells by intravenous administration of preparation. Invention can be used for immunotherapy of malignant tumors. EFFECT: valuable medicinal properties of agent. 3 cl |