| abstract |
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of 4-oxo-3,5-dihydro-4H-pyridazino[4,5-b]indol-1- acetamide of the formula (I): where X means H, methyl-, methoxy-, phenylmethoxy-group; Y means H, one or two halogen atoms, OH, ; R 1 means H, C 1 -C 4 -alkyl; R 2 and R 3 each and independently each of other means H, C 1 -C 4 -alkyl, phenylmethyl group; or R 2 and R 3 with nitrogen atom that carries their form azethidinyl-, pyrrolidinyl-, 3-ethoxypyrrolidinyl-, piperidinal-, morpholinyl-, 4-methylpiperazinyl- or 1,3- thiazolidinyl-group. Compounds of the formula (I) are agonists of ω 1 - and ω 2 -benzodi-azepine receptors located in macromolecular gamma-aminobutyric acid (GABA) complex and therefore they can be used for treatment of diseases associated with disorder of GABA-ergic transmission. EFFECT: improved method of synthesis, valuable medicinal properties of compounds. 4 cl, 1 tbl |