http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2196770-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4691facd8ee0cb3a3ee2ac35974361c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 1998-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de8feb788840492476fe96b5847b635c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1866d3f6e3a969c68616a4cea3060404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc197dc9d3ff74b752d558a9457f76c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc71dde56ab96ad9799a70e770266165 |
| publicationDate | 2003-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2196770-C2 |
| titleOfInvention | Derivatives of isoxazole, pharmaceutical composition based on thereof and method of treatment of autoimmune and inflammatory diseases |
| abstract | FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of isoxazole of the formula (1) where D means hydrogen atom; one of A and B means group (1) -E-N= C(NR 25 R 26 )NR 27 R 28 where E means a single bond or alkylene group; R 25 and R 26 each means independently hydrogen atom, C 1-4 -alkyl, -(CH 2 ) n -CO 2 R 32 where n is a whole number 1-3; R 32 means hydrogen atom, C 1-4 -alkyl, -(CH 2 ) m -CO 2 R 35 where m = 2 or 3; R 35 means hydrogen atom, C 1-4 -alkyl, -(CH 2 ) m where m is given above or -(CH 2 ) n -C(O)R 36 where n is given above; R 36 means hydrogen atom, C 1-4 -alkyl and so on; or taken in common they form with nitrogen atom 5-7-membered saturated nitrogen-containing heterocyclic group that can be substituted with one or two substituted taken among alkyl group, hydroxyl group and oxo-group; R 27 and R 28 each means independently hydrogen atom, -(CO)O-R 32 where R 32 means C 1-4 -alkyl; or R 26 and R 27 form with two nitrogen atoms and one carbon atom 5-7-membered saturated nitrogen-containing heterocyclic group that can be substituted with one or two substitutes taken among alkyl group, -(CH 2 ) m -; R 25 and R 26 mean independently hydrogen atom, C 1-3 -alkyl or -(CH 2 ) m -OH-OH and so on; (2) -E-N(R 45 )C(NR 46 R 47 )=NR 48 where R 45 means hydrogen atom, C 1-4 -alkyl, -(CO)O-R 32 ; R 48 means hydrogen atom, benzyl group and so on; and R 47 each means hydrogen atom, C 1-4 -alkyl, -(CO)O-R 32 ; or taken in common they form with nitrogen atom 5-7-membered saturated nitrogen-containing heterocyclic group and so on; one of A and B means group of the formula -J-G where G means phenyl, biphenyl, benzoylphenyl and so on; J means -C(R 8 R 9 )- or -C(=CR 8 R 9 )-, where R 8 and R 9 mean independently hydrogen atom, lower alkoxy-group, lower alkyl group and so on; or their pharmaceutically acceptable salts. Invention relates also to pharmaceutical composition used for treatment of autoimmune diseases or inflammatory diseases and comprising derivative of isoxazole of the formula (1) or its pharmaceutically acceptable salt as active component in common with pharmaceutically acceptable carrier. Invention relates also to method of treatment of autoimmune diseases or inflammatory diseases involving administration of derivative of isoxazole of the formula (1) or its pharmaceutically acceptable salt in effective amount in human body. EFFECT: new isoxazole derivatives, valuable medicinal properties of compounds. 12 cl, 1 dwg, 4 tbl |
| priorityDate | 1997-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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