| abstract |
FIELD: organic chemistry, heterocyclic compounds, pharmacy. SUBSTANCE: invention relates to novel guanidyl heterocyclic compounds of the formula (I) where R 1 means H, alkyl or absent; when R 1 absent then bond (a) is a double one, D means CR 2 where R 2 is taken among H, alkyl, halogen atom, or when B means CR 3 then D can mean N; B means NR 9 , CR 3 =CR 8 , CR 3 , S where R 9 means H, alkyl, alkenyl or alkynyl and where R 3 and R 8 are taken among H, alkyl, alkenyl, alkynyl or cyano-group; each of R 4 , R 5 , R 6 is taken independently among H, alkyl, alkenyl, alkynyl, cyano-group or NH=C(=NR 10 )NHR 11 (guanidinyl); R 10 and R 11 are taken among H, methyl and ethyl and where only one of R 1 , R 5 and R 6 means guanidinyl; R 7 is taken among H, alkyl, alkenyl, alkynyl and halogen atom. These compounds show agonistic activity with respect to alpha-2 adrenoceptors and therefore in common with pharmaceutically acceptable carrier can form pharmaceutical composition. Invention relates also to method of activation of alpha-2 adrenoceptors for prophylaxis and treatment of diseases when agonists of alpha-2 adrenoceptors are effective agents for diseases relief. EFFECT: valuable medicinal properties of compounds. 7 cl |