http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2194045-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08b0d22eaa47cc6a4af2e21e2aa606f2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-36 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-62 |
| filingDate | 1997-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85cc81152e3868b342574518b7e2e5da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7a0e98bfccfd38450c5e4f712bdd151 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35673d5d6e64430c35ba53ca6b704e86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf48ff128687030fce6cf2112ff1da51 |
| publicationDate | 2002-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2194045-C2 |
| titleOfInvention | Aminoepoxide preparation accomplished as continuous in situ synthesis |
| abstract | FIELD: organic synthesis. SUBSTANCE: invention relates to preparing aminoepoxides, in particular, chiral ones, that can be applied in chemical and pharmaceutical industries. According to invention, protected aminoaldehyde reacts with halomethyl-organometallic reagent in suitable solvent at temperature above minus 80 C. More particularly, halomethyl-organometallic reagent forms in the course of reaction of organometallic reagent with dihalomethane. Process includes following steps: feeding protected aminoaldehyde into the first mixing zone and simultaneously feeding dihalomethane into the same zone to come into contact with protected aminoaldehyde and to give the first mixture; feeding indicated organometallic reagent into the second mixing zone operated at temperature below 0 C and simultaneously feeding the first mixture into the same zone to provide contact of the first-mixture dihalomethane with organometallic reagent to form reaction mixture containing desired halomethyl-organometallic reagent; feeding thus formed reaction mixture into the third mixing zone therefrom reaction products of protected aminoaldehyde and halomethyl-organometallic reagent are discharged. Resulting aminoepoxides are useful as intermediates in synthesis of pharmaceutical preparations, for example HIV protease inhibitors. EFFECT: enhanced process efficiency. 13 cl, 34 ex |
| priorityDate | 1996-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 544.