http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2194043-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d3a84126c03f1183467a4f5a4004a31 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 1997-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0743fcb193c29da5ab0267617b6b9d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1cc1646647d1ad2a0ac4492bcf53c1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec1dd7b97c1f09fa5630b71b21175c3d |
| publicationDate | 2002-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2194043-C2 |
| titleOfInvention | Derivative of 2-(3h)-oxazolone, methods of its synthesis, pharmaceutical composition based on thereof and method of inhibition of cox-2 activity |
| abstract | FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to novel derivative of 2-(3H)-oxazolone of the formula (I) where R 1 means alkyl group or group -NR 4 R 5 where each R 4 and R 5 means independently hydrogen atom, alkyl or benzyl group; R 2 means naphthyl, unsubstituted phenyl group or phenyl group substituted with from 1 to 3 halogen atoms, alkyl group, hydroxy-, alkoxy- or trifluoromethyl-group; R 3 means hydrogen atom or alkyl group. Method of synthesis of compound of the formula (I) involves interaction of carbamate of the formula (V) with anhydrous acetic acid or interaction of mercapto-derivative of the formula (VIII) with oxidizing agent, or interaction of chlorosulfonyl of the formula (XI) with amine of the formula R 4 -NH-R 5 , or debenzylation of compound of the formula (IX) . Invention relates also to pharmaceutical composition showing anti-inflammatory effect and comprising compound of the formula (I) and pharmaceutically acceptable carrier or diluting agent. Invention relates also to method of inhibition of activity of human or animal COX-2 involving administration of compound of the formula (I) in effective amount. The claimed compounds can be used for production of medicinal agent. EFFECT: new derivatives of 2-(3H)-oxazolone, valuable medicinal properties. 18 cl, 4 tbl |
| priorityDate | 1996-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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