| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel triaryl compounds of formulas (Ia) and (Ib) or their salts where in formula (Ia) W means N or C-CO-R where R means OH, OC 1 -C 6 -alkyl or NR 3 R 4 where R 3 and R 4 mean H or C 1 -C 6 -alkyl; or in formula (Ib) Az means imidazopyridine and in both formulas (Ia) and (Ib) R 1 means C 1 -C 4 -alkyl; R 2 means phenyl fragment or 2,5-cyclohexadiene-3,4-ylidine-1-yl fragment. Compounds of formulas (Ia) and (Ib) show anti-inflammatory activity and can be used in medicine. Invention relates also to pharmaceutical composition, method of synthesis of novel compounds, method of treatment of inflammatory disease and intermediate substances. EFFECT: improved method of synthesis, valuable medicinal properties of compounds. 7 cl, 1 tbl, 28 ex |