| abstract |
FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to derivatives of piperidine of the general formula (1) and their pharmaceutically acceptable salts where R 1 means hydrogen atom, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 3 -C 8 -cycloalkyl, C 6 -C 10 -aryl that can be substituted with CH 3 , halogen atom, OR 5 where R 5 means C 1 -C 6 -alkyl, (C 1 -C 2 )-alkyl-heteroaryl comprising S, N or O as heteroatom; A means phenyl substituted with carbonyl or amino-group; B means C 6 -C 10 -aryl or C 5 -C 10 -heteroaryl comprising S, N or O as heteroatom. Invention relates to method of synthesis of compounds of the formula (1) and pharmaceutical compositions also. Compounds of the formula (1) show analgetic activity and can be used in medicine. EFFECT: improved method of synthesis, valuable medicinal properties. 11 cl, 2 tbl, 68 ex |