http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2192417-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1f5eafc9d13f674f9d39eb276c254ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c65764825883b590c9a908ddf854d55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 |
| filingDate | 2001-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94c05dfa0129d3e3b2a3d1be6fb43520 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6297f00852da7e8ee675d47d0a7e124 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08f6ca46de85ecf5ae8192c31b5e76ff |
| publicationDate | 2002-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2192417-C1 |
| titleOfInvention | Method of synthesis of substituted pyridyl(aryl)-ketones |
| abstract | FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of substituted pyridyl(aryl)ketones that can be used in organic synthesis, in production of biologically active substances, medicinal preparations and analytical reagents. Invention describes method of synthesis of substituted pyridyl(aryl)ketones by condensation of equivalent amounts of aryl bromide, alkyl lithium and derivative of arylcarboxylic acid in mixture of anhydrous organic solvents at low temperature followed by isolation of end product. Bromopyridine or substituted phenyl bromide is used as aryl bromide; methyl ester of substituted benzoic or pyridine carboxylic acid is used as derivative of arylcarboxylic acid. Condensation is carried out in mixture of tetrahydrofuran, diethyl ether, hexane and toluene in their volume ratio = 2 : 3 : 4 : 2, respectively, and at temperature (-90 C) (-110 C). The end product is isolated by decomposition of reaction mixture with water. EFFECT: improved method of synthesis, high yield of product with different substitutes in aromatic ring. 10 ex |
| priorityDate | 2001-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.