http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2191777-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4180fc57a693864e2ce2dbfd64a9278 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1999-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_990f3c84c19755b96ec7b881b5bb302a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca199151afa26f6bc597501ad589ab87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36624c864de805d6779f6e16022ea237 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3606cdd1ba21520adb156f58285c070d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a0ed65da45634efc4d0bc0057116f4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39e57e8ab94b32d7dbd5f0ea1b1ebfe3 |
| publicationDate | 2002-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2191777-C2 |
| titleOfInvention | 6,9-disubstituted 2-[trans-(4-aminocyclohexyl)-amino]purines |
| abstract | FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention relates to novel compounds of the general formula (I) where R is taken among group comprising of R2, R2NH- or H 2 N-R3- where R2 is taken among group comprising of C 1 -C 8 -alkyl and compound of the formula (II) where Z is taken among group consisting of phenyl, heterocycle and cycloalkyl; each R4 means independently hydrogen atom or C 1 -C 4 -alkyl and n is whole number = 1-8; where each C 1 -C 8 -alkyl and z are substituted optionally with 1-3 substitutes that can be similar or different and taken among group consisting of Hal, OH and C 1 -C 4 -alkyl; R3 means C 1 -C 8 -alkylene; and R1 is taken among group consisting of cyclopentyl and isopropyl. Invention relates to their pharmaceutically acceptable salts, optical isomers and hydrates also. Except for, invention presents method of inhibition of cellular cycle development, method of inhibition of cycline-dependent kinase activity, especially, cdk-2, method of prophylaxis of apoptosis in neuron cells and method of inhibition of blastomas development and composition comprising effective amount of compound of the formula (I) and pharmaceutical composition comprising effective inhibitory amount of compound of the formula (I) in mixture with or another combination with one or some pharmaceutically acceptable carriers or excipients. EFFECT: valuable medicinal and biochemical properties of compounds. 34 cl, 2 tbl, 62 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11702417-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2553668-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2462246-C2 |
| priorityDate | 1998-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1919.