| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel ergoline derivatives of the formula (I) where R 1 is H or group where n = 1-4; R 7 means F, Cl, C 1 -C 4 -alkyl; R 2 means H, Cl, Br, J, C 1 -C 4 -alkyl, C 1 -C 4 -alkylthio-group; R 3 means H, C 1 -C 4 -alkyl; R 4 means (i) group of formulas (c) , (d) where R 8 means H, NO 2 ; R 11 means C 1 -C 4 -alkyl, C 2 -C 8/ -alkenyl or (ii) group of formulas (e) , (f) ; R 5 and R 6 mean H or in common they form additional bond. Compounds of the formula (I) are selective antagonists of somatostatin sst 1 -receptor and can be used as medicinal agents for treatment of depression, fear state, bipolar disorders and attention deficiency and disorders associated with hyperactivity. EFFECT: improved method of synthesis, valuable medicinal properties. 7 cl, 2 tbl |