| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of benzodioxol, benzofuran, dihydrobenzofuran and benzodioxane or their pharmaceutically acceptable solvates of the general formula (I): where Q 1 and Q 2 each means independently hydrogen or halogen atom; X means CH 2 , CH or O-atom; Y means CR 2 or CR 3 , CR 3 R 4 where n = 1-4; Z means (CH 2 ) n , CH or O-atom; R means hydrogen, halogen atom or CH 2 -alkyl in both cases; m = 1 or 2; C 1-4 means R 1 -alkyl, C 1-6 -cycloalkyl, C 3-6 -haloidalkyl, C 1-3 -alkylamino-group, C 1-6 -alkenyl, C 2-6 -alkoxy-C 1-4 -alkyl, C 1-4 -alkylthio-C 1 -C 4 -alkyl or trifluoromethylalkyl-C 1-4 ,; R 2 means hydrogen, halogen atom or C 1-4 -alkyl; and R 3 and R 4 each means independently hydrogen atom or C 1-4 -alkyl. Invention relates to pharmaceutical compositions comprising said compounds used for therapy of sleep disorders and disorders associated with circadian rhythm impairment. EFFECT: valuable medicinal properties. 17 cl, 2 tbl, 102 ex |