| abstract |
FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to novel ketobenzamides of the formula (I) where R 1 means phenyl, naphthyl, quinolyl, pyridyl, quinazolyl, quinoxalyl, benzothienyl, isoquinoline, tetrahydroisoquinoline or tetrahydroquinoline that can be both unsubstituted and substituted; R 2 means hydrogen atom or alkyl; R 3 means alkyl that can carry phenyl ring; X means a bond, -(CH 2 ) m , -(CH 2 ) m -O-(CH 2 ) 0 -, -(CH 2 ) n -S-(CH 2 ) m -, -CH= CH-, -CO-CH= CH-, ; R 4 means groups OR 6 , NR 7 R 8 ;; n is a number from 0 to 2. Compounds of the formula (I) show an inhibitory activity and therefore they are inhibitors of cysteine proteases, in part for example, calpain I and II and cathepsins B and L. EFFECT: valuable biochemical properties. 3 cl, 1 tbl, 41 ex |