| abstract |
FIELD: medicine, oncology. SUBSTANCE: invention relates to the improved systems of directed tumor therapy using enzyme and prodrug compound, in part, antibody-mediated therapy using enzyme and prodrug (ADEPT). Enzyme using in the system presents a mutated form of enzyme of the host cell where natural enzyme of the host cell, for example, ribonuclease disposes its natural substrate by means of interaction of ions pair. This interaction of mutated enzyme and prodrug compound in the system is a reverse one (i. e. the reverse polarity). EFFECT: expanded arsenal of antitumor agents. 20 cl, 33 dwg |