| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of imidazole of the general formula (I) where n = 0 or 1; R 1 is hydrogen atom, alkyl; R 2 is hydrogen atom, or R 2 and R 3 form a double bond; R 3 is hydrogen atom, alkyl; R 4 is hydrogen atom, alkyl, hydroxy-group, alkoxy-group; R 5 is hydrogen atom or alkyl, or R 4 and R 5 form carboxyl group; R 6 ,R 7 ,R 8 are hydrogen atom, alkyl, hydroxy-group, alkoxy-group, hydroxyalkyl, halogen atom; X is -CHR 9 -(CHR 10 ) m - where m = 0 or 1; R 9 and R 10 mean hydrogen atom or alkyl. Compounds of the formula (I) show α 2 --agonistic activity and therefore they can be used as an active component of a pharmaceutical composition. EFFECT: valuable medicinal property of compounds. 15 cl, 2 tbl |