| abstract |
FIELD: medicine, oncourology. SUBSTANCE: it is suggested to conduct polychemotherapeutical course in pre-operational period according to VAB-6 scheme: bleomycin 30 mg intramuscularly, vinblastine 4 mg/m 2 intravenously, cyclophosphane 600 mg/m 2 intravenously - the 1st d; cisplatine 100 mg/m 2 is added to 150 ml autoblood to conduct incubation of the mixture in a thermostat followed by reinfusion - the 2nd d; 7-10 d later an operative interference is carried out - high funiculorhectomy, 7-10 d after operation the injection of antitumor preparations should be repeated: bleomycin 30 mg/m 2 intramuscularly, vinblastine 4 mg/m 2 intravenously, cyclophosphane 600 mg/m 2 intravenously - the 1st d, on the 2nd d two sterile vials per 150 ml patient's autoblood are supplemented with etoposide 100 mg/m 2 into the first vial and cisplatine 100 mg/m 2 into the second one, incubation in a thermostat is conducted for 30 min followed by reinfusion of the first vial and then the second one. Such therapeutical courses are repeated once or twice at an interval of 10-14 d. The method enables to decrease metastasis process, toxicity of chemopreparations, amount of complications and prolong the terms of remission. EFFECT: higher efficiency of therapy. |