http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2187812-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c834e3599be9b40719320c8f10a8a777 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2001-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21332030c858bbd3017f9df641864d1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86dbf3ba43477f1368a0dbaf5657970e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0cf28ce8ee71bee19bb8b8b6a692d14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3316f7995c3ac1c8c3076f27ae9c2d4 |
| publicationDate | 2002-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2187812-C1 |
| titleOfInvention | Method for predicting the development of iron deficiency anemia (variants) |
| abstract | FIELD: medicine, hematology. SUBSTANCE: it is conducted the analysis of polymorphous loci of P-4501A1 cytochromic gene due to polymerase chain reaction of DNA synthesis, it is conducted in DNA isolated due to phenol-chloroform extraction technique out of lymphocytes of peripheral venous blood. After amplification and extraction DNA fragments are electrophoretically divided in 7%- polyacrylamide nondenaturated gel and analyzed under ultraviolet lighting by using a transulluminator: the presence of DNA-fragments at the size of 48 and 139 nucleotide pairs (np) is interpreted as isoleucin allele (Ile), at the size of 48, 120 and 19 np - as valine (Val). Relative risk of disease development (RR) is concluded on at RR>1.5. At revealing Ile/Val genotype it is predicted the risk of IDA development (variant 1). Then it is conducted the analysis of polymorphous loci of glutathione S-transferase M1 genes (GSTM1), N-acetyltransferase 2 (Nat2), angiotensin converting enzyme (ACE) and plasminogene activator (PA) due to the method of polymerase chain reaction of DNA synthesis (PCR) and at revealing genotype combinations of 0/0,S/R,I/D,I/D; +/+,R/R,I/I,I/D; +/+,S/S,I/D,I/D; +/+,S/R,I/I, I/D; +/+,S/R,D/D,I/I the risk of iron deficiency anemia development is predicted. EFFECT: higher accuracy of prediction. 2 cl, 2 ex, 1 tbl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2582763-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022117923-A1 |
| priorityDate | 2001-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.