| abstract |
FIELD: organic chemistry. SUBSTANCE: invention relates to novel derivatives of biphenylamidine of the formula (I) A means -O-C m H 2m -X 1 - or means formula (II) where X 1 means oxygen atom or formula (III) ; R 1 means cycloalkyl with 5-7 carbon atoms, Ar 1 ,CR 4 R 5 Ar 2 ,C(CH 3 ) 2 R 6 ; R 2 means hydrogen atom, alkyl, hydroxyl, halogen atom, O-alkyl; R 3 means hydrogen atom, alkyl; R 4 means alkyl, trifluoromethyl-group, CH 2 OH; R 5 means hydrogen atom, alkyl, trifluoromethyl-group; or R 4 and R 5 in common can form alkylene; R 6 means CH 2 OH,CONR 7 R 8 ,CH 2 R 7 R 8 under condition that R 1 does not mean unsubstituted phenyl residue bound through alkylene, or their acid-additive salts with pharmacologically acceptable acids. EFFECT: new compounds indicated above. 4 cl, 1 ex |