| abstract |
FIELD: organic chemistry, heterocyclic compounds, pharmacy. SUBSTANCE: invention relates to novel derivatives of oxadiazole of the general formula (I) where X and Y mean oxygen or nitrogen atom being X and Y can not be oxygen or nitrogen simultaneously; Z means radical of the formula (II) ; means phenyl radical that can be substituted directly or through alkylene bridges with number of carbon atoms from 1 to 4 by two- fold or threefold with one or some substituents taken among the order: halogen atom, R 1 -alkyl, C 1 -C 4 . Derivatives of oxadiazole of the general formula (I) can be used as drugs in neurodegenerative diseases and brain ischemia of different genesis: epilepsy, CF 3 -NR 5 R 6 ,NO 2 ,-OR 7 , hypoxia, anoxia, brain trauma, brain edema, amyotropic lateral sclerosis, Huntington chorea, Alzheimers's disease. EFFECT: new compounds indicated above, valuable medicinal properties. 8 cl, 6 tbl, 10 ex _ |