| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of [(1'R),2R,3S,-4S,5R,6R,9R,11R,12R,14R]-11-(1'-hydroxypropyl)-2,4,6,8,11,-14-hexamethyl-10,13,15-trioxatricyclo-9.2.1.1. 9.6 -pentadecane-1-one of the general formula (I) where R 1 means methyl or hydrogen atom and to their stable and physiologically acceptable salts. Invention describes method of synthesis of these derivatives by treatment of compounds of the formula (II) with acid. Also, invention describes a medicinal agent used for treatment and/or prophylaxis of disorders of motility of gastroenteric tract, gastroesophageal reflux, dyspepsia and/or disorders of stomach evacuation that contains pharmacologically effective amount of compound of the formula (I). EFFECT: improved method of synthesis, valuable medicinal properties. 4 cl, 1 sch, 3 ex |