http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2180901-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate | 1997-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b54c8b18bea5eaebdf9517bad3826c27 |
| publicationDate | 2002-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2180901-C2 |
| titleOfInvention | N-substituted 2-cyanopyrrolidines |
| abstract | FIELD: biologically active compounds. SUBSTANCE: invention provides N-(N'-substituted glycyl)-2- cyanopyrrolidine of formula I: (I), wherein R denotes (i) R 1 R 1a N(CH 2 ) m -, in which R 1 is pyridinyl or pyrimidinyl moiety optionally independently mono- or disubstituted by halogen, trifluoromethyl, cyano, or nitro; R 1a denotes hydrogen or C1-C8-alkyl; and m = 2 or 3; (ii) C3-C12-cycloalkyl optionally substituted by hydroxy- C1-C3-alkyl in position 1; (iii) R 2 (CH 2 ) n -, in which either R 2 is phenyl optionally independently mono-, di- or trisubstituted by C1-C4-alkoxy, halogen, or phenylthio group, in turn optionally substituted by hydroxymethyl in benzene ring; or R 2 is C1-C8- alkyl, [3.1.1]bycyclo-carbocyclic moiety optionally mono- or multisubstituted by C1-C8-alkyl, and further pyridyl, naphthyl, cyclohexenyl, or adamantyl; and n = 1-3; or R 2 is phenoxy group and n = 2; (iv) (R 3 ) 2 CH(CH 2 ) 2 -, in which each R 3 independently denotes phenyl; (v) R 4 -(CH 2 ) p -, in which R 4 is 2-oxopyrrolidinyl or C2- C4-alkoxy and p = 2-4; (vi) isopropyl optionally substituted by C1-C3- hydroxyalkyl in position 1; (vii) R 5 , which denotes indanyl-piperidinyl moiety optionally substituted by benzyl, [2.2.1]- or [3.1.1]bycyclo-carbocyclic moiety optionally mono- or multisubstituted by C1-C8-alkyl, adamantyl, or C1-C8-alkyl in turn optionally mono- or multisubstituted independently by hydroxy, hydroxymethyl, or phenyl in turn optionally mono- or disubstituted by C1-C4- alkyl, C1-C4-alkoxy, or halogen; in free form or in the form of acid addition salt. Compounds I can be used in pharmaceutical composition inhibiting DPP-1y, in particular for treatment of diabetes mellitus, insulin-independent diabetes, and conditions caused by decreased tolerance to glucose. EFFECT: increased choice of antidiabetics. 6 cl, 2 tbl, 2 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-021236-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2574410-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2443687-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2507197-C2 |
| priorityDate | 1996-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 235.