| abstract |
FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention relates to novel derivatives of phenyloxazolidinone that have C-C-bond with 4-8-membered heterocyclic rings of the formula (I) and their pharmaceutically acceptable salts where X means NR 1 , S(O) q or O; R 1 means H, C 1-6 -alkyl optionally substituted with one or some CN-groups or halogen atom, -(CH 2 ) h -phenyl, -COR 1-1 , -COOR 1-2 , -CO-(CH2) h -COR 1-1 , -SO 2 -C 1-6 -alkyl or -(CO) i -Het; R 2 means H, -CO-(CO 1-6 )-alkyl or fluorine atom; R 3 and R 4 are similar or different and mean H or halogen atom; R 5 means C 1-6 -alkyl and C 3-6 -cycloalkyl optionally substituted with one or some halogen atoms; g = 0, 1 or 2; h = 1 or 2; i = 0 or 1; m = 0, 1, 2, 3; n = 0, 1, 2, 3 under condition that m and n taken in common = 1, 2, 3, 4 or 5. EFFECT: improved synthesis of novel derivatives of phenyloxazolidinone with C-C-bond with 4-8-membered heterocyclic rings. 12 cl, 2 tbl |