http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2173316-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate | 1996-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2173316-C2 |
| titleOfInvention | Novel heterocyclic derivatives and their pharmaceutical using |
| abstract | FIELD: organic chemistry, heterocyclic compounds, pharmacy. SUBSTANCE: invention relates to novel heterocyclic derivatives of the formula (I) where one of R 1 ,R 2 ,R 5 is carboxy-group, C 2 -C 5 -alkoxycarbonyl, C 1 -C 8 -alkyl, substituted hydroxy-group, carboxy-group, C 2 -C 5 -alkoxycarbonyl or the group of the formula -NR 9 R 10 where each of R 9 ,R 10 means independently C 1 -C 6 -alkyl and each of two others means independently hydrogen atom, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy-group; R 3 or R 4 means the group -NHCO-R 7 where R 7 means C 1 -C 20 -allyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkylthio-C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkyl-C 1 -C 3 -alkyl, phenyl, phenyl-C 1 -C 4 -alkyl, the group -NHR 8 where R 8 means C 1 -C 20 -alkyl and others are hydrogen atom, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy-group; R 6 means C 1 -C 20 -alkyl, C 3 -C 12 -alkenyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkylthio-C 1 -C 6 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8/ -cycloalkyl-C 1 -C 3 -alkyl, phenyl-C 1 -C 4 -alkyl; Z means the formula: and it is a binding group with nitrogen atom under condition that when one of R 1 ,R 2 ,R 5 is carboxy-group or C 2 -C 5 -alkoxycarbonyl then Z is the group or . Compounds of the formula (I) are inhibitors of enzyme acyl-Co:cholesterol acyltransferase and lipid peroxidation process and can be used in pharmaceutical composition. EFFECT: new compounds indicated above, valuable medicinal and biochemical properties. 23 cl, 20 tbl, 167 ex |
| priorityDate | 1995-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 261.