| abstract |
FIELD: organic chemistry, medicine. SUBSTANCE: invention describes novel substituted liposaccharides of the formula (I) where R 1 means the group of the formula (a) where J and K are linear C 1 -C 15 -alkyl; R 2 means linear C 5 -C 15 -alkyl; R 3 means the group of the formula (b) where A and B mean linear C 1 -C 15 -alkyl; R 4 means the group of the formula (c) where each U and V means linear C 2 -C 15 -alkyl and W means linear C 1 -C 5 -alkyl; R A means R 5 -O-CH 2 - where R 5 means linear C 1 -C 5 - -alkyl; R 6 means hydroxy-group; A 1 and A 2 means the group of the formula (d) , or their pharmaceutically acceptable salts. Compounds can be used for prophylaxis and constructive treatment of patients with endotoxin effect including sepsis, septicemia, endotoxicosis and different forms of septic shock. EFFECT: new compounds indicated above, valuable medicinal properties. 14 cl |