| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel compounds with nucleus formed by two condensed six-membered rings A and B of the formula (I) or pharmaceutically acceptable salt, solvate or prodrug derivative of this compound where bicyclic nucleus with rings A and B is taken among the group consisting of the formulas (17) , (18) , (19) , (20) , (21) ; R 3 is an acidic group containing acidic radical taken among formulas of the group (C) ; n = 0-6; R o is similar or distinct and taken independently from hydrogen atom, alkyl; binding group -(L)- is a bond or taken among formulas: -C(=O)-N(H)- and -C(H 2 )-O-; Q is basic group and taken among amidino-group and piperidine. New bicyclic compounds are useful as preparations neutralizing effect of glycoprotein IIb/IIIa for thrombosis prevention. Invention describes also method of inhibition of platelets adhesion and composition for its realization. EFFECT: new compounds indicated above, improved method of inhibition, valuable medicinal properties. 25 cl, 1 tbl, 105 ex |