| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes derivatives of aniline of the formula (I) where R 1 means SR 6 or NR Y R 8 ; R 6 means direct or branched alkyl group and others; R 7 means hydrogen atom, direct or branched alkyl group and others; R 8 means hydrogen atom, direct or branched alkyl group; R 2 means hydrogen atom, direct or branched group and others; R 3 means hydrogen atom or direct or branched alkyl group and others; R 4 means hydrogen atom, direct or branched alkyl group and others; R 5 means hydrogen atom, direct or branched alkyl group and others; Y 1 ,Y 2 ,Y 3 ,Y 4 mean hydrogen, halogen atom, hydroxy-group and others; n and m each = 0 or 1, or possible stereoisomers or optically active forms of compounds or their pharmaceutically acceptable salts. Compounds show strong inhibitory effect on activity of NO-synthase and they are used as therapeutic agents for treatment of patients with cerebrovascular diseases, for example, cerebral hemorrhage, cerebral infarction, brain edema and others. EFFECT: new compounds, valuable medicinal properties. 95 cl, 2 dwg, 51 tbl, 656 ex |