| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel naphthyl derivatives of the formula (I) where R 1 and R 2 mean H, -OH or -O-(C 1 -C 4 -alkyl); R 3 means 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholinyl, dialkylamino- or 1-hexamethyleneimino-group; n = 2 or 3, or their pharmaceutically acceptable salts. Compounds of the formula (I) inhibit manifestation of postclimacteric syndrome symptoms and can be used as an agent for relief of postclimacteric syndrome symptoms as osteoporosis, cardiovascular diseases, hyperlipidemia or hormone-dependent cancer. Invention describes also intermediate compounds of the formula (II) where R 1a is H or OR 5 ; R 2a is H or OR 6 ; R 5 and R 6 means hydroxy-protective group; R 4 means -OH or -CHO. EFFECT: new compounds, improved method of synthesis, valuable medicinal properties. 13 cl, 6 tbl, 6 ex |