| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel small di- and trivalent inhibitors of selectin of the formula (II) where X is taken among the group including -CN, -(CH 2 ) n CO 2 H,-(CH 2 ) n , CO-NH-OH, , -OH; Y is -(CH 2 ) f ; R 1 ,R 2 are taken independently among the group including hydrogen atom, lower alkyl, halogen atom, -OZ, -NO 2 ,-NH 2 ; R 3 is taken among the group including hydrogen atom, lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, lower alkyl-carboxylic acid; f = 1-6; n = 0-2; b = 0-2; m = 1-3; Z means lower alkyl, phenyl, or to their pharmaceutically acceptable salts, esters, amides. Invention relates to also pharmaceutical composition based on new compounds and method of inhibition of E-selectin or P-selectin binding with sLe x or sLe a . EFFECT: new compounds indicated above, improved method of inhibition. 9 cl, 1 tbl, 10 ex |