http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2163263-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c834e3599be9b40719320c8f10a8a777 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02 |
| filingDate | 1999-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a69680c52b4e858f9a3ca30687ba6bd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0eb8eac0f0a9edb68253910bf2906e69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e422dbb0677596bf9d314baec76a1d7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4021d20d676986dd1d2401b0caa520e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4932ff3ff81471a6e79198421a4460d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3581f4ed9aadebc9ba47365d0d9db75d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_746b51ff39b0b9ab0e286e33743b172d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d905c09ae2e29d454702d72658e84f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03120d696d8412b5933d7789ee6c9b6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4089bb91567b81903919ecfc240734c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae51965b7a52e9781ec81554638f9a49 |
| publicationDate | 2001-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2163263-C1 |
| titleOfInvention | Strain of bacterium citrobacter diversus n 256 showing pathogenicity factors complex |
| abstract | FIELD: microbiology. SUBSTANCE: invention relates to preparing thermolabile enterotoxin and anatoxin from Citrobacter diversus in vaccines producing. Strain is isolated from feces of patient with acute intestine infection and deposited in Collection of the State Scientific- -Research Institute of standardization and control of medicinal biological preparations at number 256. Citrobacter diversus GISK N 256 shows the following traits: strain grows on usual universal solid nutrient media forming typical isolated colonies. In beef-extract broth strain causes the uniform turbidity, precipitate formation and film formation on surface. Subplantar (model of paw edema) administration in mice (weight 15-16 g) of 0.05 ml of centrifugate of 20 h broth culture causes paw edema with difference above 120 mg. Intranasal administration of 80 mln of bacterial cells causes the death of 95% of mice-male (weight 15-16 g) for 1.5 h. Intracutaneous administration of 300 mln of bacterial cells of 20 h broth culture causes skin necrosis in rabbits (diameter above 3.5 cm). In experiment with rabbit intestine loop administration of the strain in the dose 500 mln of bacterial cells gives the positive effect (V/L = 1.2). Centrifugate of 20 h broth culture heated at 56 C for 45 min causes paw edema in mice (below 30 mg) but does not cause skin necrosis in rabbits. Heated 20 h culture (at 100 C) does not cause fluid accumulation in rabbit intestine isolated loop (V/L = 0.3). Conditions and medium composition for multiplication: Hottinger's broth (pH 7.2-7.4), 1.5% beef-extract broth at 37 C for 18-24 h. EFFECT: increased toxin-producing capacity of strain of bacterium Citrobacter diversus GISK N 256. |
| priorityDate | 1999-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.