| abstract |
FIELD: medicine. SUBSTANCE: described are new cyclohexapeptides of formula I: cyclo A- B-C-Y-F-(D) Ala (1) wherein A, B, E and F independently from each other are Val or Tyr, if B and F are Tyr; A and E are Val, and if A and E are Tyr, B and F are Val. C = Xaa is natural amino acid residue, except for cysteine and tryptophan and are Gly, Ala, Val, Leu, Ile, Pro, Tyr, Thr, Phe, His, Ser, Met, Lys, Arg, Asp, Asn, Glu, Gln, and also physiologically acceptable salts thereof. They inhibit specifically bond of interleikin-4 (IL) with IL-4 receptor and inhibit activity of IL-4. In view of this fact above-mentioned compounds are useful both for therapy and prophylaxis and diagnosis of allergies and infections. EFFECT: improved properties of the title compounds. 17 cl, 9 dwg, 7 ex |