| abstract |
FIELD: chemical industry. SUBSTANCE: described are condensed tropanic derivatives of formula I: wherein X and Y together form =O,=,NOR 3 ,=CR 3 R 4 , either one of X and Y is hydrogen an the other is -OR 5 ,SR 5 ,-NR 5 R 6 ; Z is hydrogen; R 3 and R 4 are independently hydrogen, lower alkyl, lower alkenyl, phenyl (lower alkyl) or -(CH 2 ) q -COOR 2 ; R 2 ,R 5 ,R 6 are independently hydrogen, lower alkyl, lower alkenyl, - CO-(lower alkyl), phenyl (lower alkyl) or -SO 2 -(lower alkyl); R 1 is lower alkyl or phenyl optionally substituted by halogen, CF 3 , CN, lower alkyl or nitro; n is 1 or 2; q is 0. Said compounds are useful as medicinals having properties of inhibiting reverse capture of neutromediatory monoamines in central nervous systems. EFFECT: improved properties of the title compounds. 8 cl, 30 ex, 3 tbl |