| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes substituted amides of the formula (I) TNF α where TNF α means substituted phenyl; is alkyl, phenyl, pyridyl, heterocyclyl and others; R 1 is ethylene, vinylene, branched alkylene and others; R 2 means R 3 , -CX where X is O or S. Compounds of the formula (I) have capability to decrease the level of R 4 and inhibit CH 2 -activated replication of retroviruses and therefore they can be used for control of cachexia, endotoxic shock and replication of retroviruses. Compounds of the formula (I) are synthesized by interaction of substituted amine with corresponding anhydride, phthalimide or aldehyde. EFFECT: improved method of synthesis, valuable antiviral properties. 21 cl, 13 ex |