| abstract |
FIELD: pharmaceutical chemistry. SUBSTANCE: novel pharmaceutical form consists of three phase, one of which being a coating. The first phase contains amorphous active ingredient, water-soluble polymer (polyvinylpyrrolidone), cellulose ether, and surfactant. The second phase contains cellulose ether and mixture of mono-, di-, and triglycerides. The third phase is scarcely soluble in water or stable-in-stomach film coating composed of ester of hydroxypropylmethylcellulose with phthalic anhydride or methacrylic acid/ethyl acrylate copolymer. EFFECT: prolonged constant-rate release period up to 24 h. 68 cl, 1 dwg, 9 tbl, 8 ex |