abstract |
FIELD: organic chemistry, antibiotics, pharmacy. SUBSTANCE: invention relates to novel crystalline acid salts addition of cephem of the general formula (I) where n = 1 or 2; m = 0.4-2.6 and X means anion of hydroxy-carboxylic acid that show antibacterial activity. Salts of the formula (I) are produced by interaction of water-soluble salt of the formula (I), for example, sulfate salt with corresponding salt of carboxylic acids (II-V) given in the invention description. Invention relates to also drug based on acid salt of cephem of the formula (I) and acceptable vehicle. EFFECT: new crystalline addition acid salts of cephem as drug. 6 cl, 3 tbl, 1 dwg, 30 ex |