http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2160741-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1996-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2012201888c75cd80002d710e6891b5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e19dfb29c84bd65a58361b7398fd3833 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0044705d5ab123300974ddd2d456b30a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7bb32887c82aeed36c3002de2a46c59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b235b360dd141df9fc4a7023de9545d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1bed5b2a65186308956fa70261f6b9c |
| publicationDate | 2000-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2160741-C2 |
| titleOfInvention | Somatostatine peptides |
| abstract | FIELD: organic synthesis. SUBSTANCE: invention provides novel hexapeptide of formula II: [A-Zz a -(D/L)Trp-Lys-X 1 -X 2 ] (II), in which X 1 is radical of formula a: (a) or b: (b), wherein R 1 optionally substituted phenyl and R 2 is group -Z 1 -CH 2 -R 1 , -CH 2 -CO-O-CH 2 -R 1 , or c: (c) or d: (d), wherein Z 1 is oxygen or sulfur atom; X 2 is alpha-amino acid substituted by aromatic radical on its side C α chain or X 2 is amino acid motif Dab; A is bivalent residue selected from: Pro, (R 3 -NH-COO)Pro, H 2 N-Pro, HO-Pro, R 3 -NH-CO-O- R 6 -CH(NR 4 )-CO-, , where R 3 is NR 8 R 9 -(C 2 -C 6 )-alkylene or guanidine-C 2 -C 6 -alkylene; R 4 is hydrogen or methyl; R 11 benzyl optionally substituted in its ring, -(CH 2 ) 1-3 -OH or -(CH 2 ) 1-5 -NH 2 ; R b is -(CH 2 ) 1-3 ; each of R 8/ and R 9 , independently from each other, are hydrogen, (C 1 -C 4 )-alkyl, acyl, or CH 2 OH-(CHOH) c -CH 2 -, where c = 0, 1, 2, 3 or 4, or R 8 and R 9 form with nitrogen atom, to which they are linked, heterocyclic group, which can contain additional heteroatom (examples: pyridyl or morpholino groups); and Zz a is natural or synthetic alpha-amino acid unit selected from: Ala, Val, Thr, Ser, Leu, Nle, Ile, His, Trp, Arg, Tyr, Phe, and NH 2 -Phe in free base form or in the form of salt or complex compound. Compounds of invention have affinity for somatostatin receptors. EFFECT: extended choice of biologically-active polypeptides. 7 cl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014116144-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2547940-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9382306-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2526822-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2457215-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012138251-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-034753-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2528414-C1 |
| priorityDate | 1995-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 341.