| abstract |
FIELD: biotechnology, more particularly of nucleic acids into cells. SUBSTANCE: in order to deliver nucleic acids, cell is maintained with compound having formula: w...x-y-NH-CR 4 (CH 2 OR 1 )(CH 2 OR 2 ) wherein w is nucleic acid, x is peptide of amino acid, y is linker having chain which is equivalent to 1-20 carbon atoms or is not existent; R 4 is H or CH 2 O-R 3 , and R 1 ,R 2 and R 3 are identical or different and are either hydrogen, methyl, ethyl, hydroxy or acyl, group prepared from fatty acid having carbon chain containing 3-24 saturated or unsaturated carbon atoms provided that at least one radical R 1 , R 2 and R 3 is acyl group prepared from fatty acid or compound of formula (2): w...x-yNHCH 2 CH 2 OR 5 , wherein w is nucleic acid, x is peptide or amino acid, y is linker having chain which is equivalent to 1-20 carbon atoms, or it not existent, R 5 is acyl group prepared from fatty acid having carbon chain containing 3-24 saturated or unsaturated carbon atoms. Invention makes it possible to deliver gene therapeutic drug into cells. EFFECT: more efficient of nucleic acids. 44 cl, 40 dwg, 4 tbl |