http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2160256-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1cbd719b490709d9a85ee82ae0458ed2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
| filingDate | 1996-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1dcdb96f19c3f6fb523b837bd768253 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6698453107c5924754be47d4d31dc2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf51f1747d35095588d16fea206a835d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1980f550a45b6ebf68e7d8768a5d47ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c45e08cea28facf1585b52f4181d49e |
| publicationDate | 2000-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2160256-C2 |
| titleOfInvention | Acetamide derivatives (variants), method of preparation thereof (variants), pharmaceutical composition and agent |
| abstract | FIELD: pharmaceutical industry, medicine. SUBSTANCE: described are new acetamide derivatives of formula I: wherein X is -O- or -NR 4 ; R 1 is hydrogen atom, lower alkyl group, lower alkenyl group or cycloalkyl lower alkyl group; R 2 is lower alkyl group; C 3 -C 7 -cycloalkyl group; phenyl group; phenyl group substituted by halogen atom or lower alkoxy group; or phenyl lower alkyl group; or optionally R 1 and R 2 together with nitrogen atom to which they are attached from group of formula (a): wherein A is single bond, -CH 2 - or NH-; R a and R b are identical or different and each is hydrogen atom or lower alkyl group; or when A is single bond, and R a and R b are in position 2 and in position 3, carbon atoms in position2 and in position 3, and R a and R i are optionally combined to form phenyl ring; R 3 is hydrogen atom, lower alkyl group or hydroxylower alkyl group; R 4 is hydrogen atom or lower alkyl group or R 3 and R 4 are optionally combined with carbon atom and nitrogen atom to which they are attached to form pyrrolidine, piperidine or 2,3-dihydro-1H-indole ring; R 5 is hydrogen atom, lower alkyl group, hydroxylower alkyl group, halogen atom, amino group, lower alkanoylamino group, nitro group; or lower alkoxycarbonyl group; R 6 is hydrogen atom, lower alkyl group, trifluoromethyl group or phenyl group, or R 5 and R 6 are optionally combined to from (CH 2 ) n (n is 3,4,5, or 6); R 7 is hydrogen atoms, halogen atom, lower alkyl group, lower alkoxy group, trifluoromethyl group, amino group or nitro group; R 8 is hydrogen atom or halogen atom; or pharmaceutically acceptable acid addition salt thereof. Said compound have selected effect on BZω 3 which is peripheral type receptor and show high pharmacological activity. They are therefore useful for prophylaxis or treatment of central nervous system diseases such as diseases associated with symptoms of anxiety and also depression, epilepsy or the like. Also described are methods of preparing compounds of formula I and pharmaceutical composition and agent based thereof. EFFECT: improved properties of the title compounds. 18 cl, 21 tbl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8466282-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9221836-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8664380-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9045436-B2 |
| priorityDate | 1995-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 471.