| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel polycyclic compounds of the formula (I) or their pharmaceutically acceptable salt where A is aromatic or heteroaromatic ring taken among the group including (a) , (b) , (c) ; B is aromatic or heteroaromatic ring taken among the group including the group (d) ; Z means the bond, -C(= O), -O-, -S(=O)- or -SO 2 ; R means phenyl; R 2 means H, -1, -R 4 , -OR 4 , -OH, -COOR 4 - -(CH 2 ) , -(CH 2 ) n C=CR 5 , -(CH 2 ) n NR 6 COR 4 or -NR 6 R 6a ; R 3 means H or OR 4 ; R 2a means H, C 1 -C 4 -alkyl or phenyl; R 4 is C 1 -C 4/ -alkyl; R 5 , R 6 , R 6a each independently means H or C 1 -C 6 -alkyl; n = 0 or 1; R is taken among the group including H, -(CH 2 ) n -(Het-2) or (CH 2 ) n -Y where Het-1 and Het-2 each independently means heterocycle taken among (e) where X means H, Cl, F, Br or OR 4 ; n = 1, 2 or 4; y means -OR 6 , -CO 2 R 6 , -CN or CONHR 6 under condition that when A means hexa-membered aromatic or heteroaromatic ring then Het-1 and Het-2 both are not (f) where X means H. Compounds of the formula (I) enhance secretion of neurotrans-mitter acetylcholine and therefore can be used for treatment of patients with diseases where its content is decreased, for example, in Alzheimer's diseases and other states including teaching and intellectual activity. Invention describes also their derivatives, pharmaceutical preparations based on compounds (I) and method of treatment of patients with intellectual activity disorders. EFFECT: improved method of synthesis, valuable medicinal properties. 13 cl, 2 dwg, 4 tbl, 112 ex |